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Principal Researcher Drug Metabolism, DMPK

Company Eisai, Inc.
Location Andover, MA
Job Title Principal Researcher, Drug Metabolism, DMPK
Department DMPK US
Job Type Full Time
Auto req ID 3933BR
To apply: Click here

  Job Description:  
  The primary role of the position is to conduct and develop in vitro metabolism studies to support discovery and development project. The duties also include preparation of method protocols, analysis of in vitro samples using LCMS, presentation of experimental results to project teams, and compiling metabolism reports for regulatory submissions. The results generated may have direct or indirect impact on projects advancement/discontinuation.  
  Job Responsibilities:  
  • Perform various in vitro ADME experiments, including metabolic stability using microsomes and hepatocytes isolated from various species, CYP inhibition/TDI, protein binding, and reaction phenotyping.
  • Operate LC/MS/MS instruments independently, and develop LC/MS/MS method to separate and detect small molecules.
  • Familiar with standard data analysis software packages used in the industry such as GraphPad, or other similar software packages.
  • Maintain laboratory notebook and complete all documentation according to the standard operating procedures.
  • Strong interpersonal and excellent verbal and written communication skills.
  Job Qualifications:  
  • B.S./M.S. in Biology, Chemistry, Pharmaceutical Sciences or other relevant field; BS with 2-4 years of related experience /M.S. with 0-2 years of relevant experience
  • Experience with in vitro ADME studies and analytical techniques (HLPC and Mass Spectrometry).
  • Experience with tissue culture /aseptic techniques.
  • Must be detail oriented and highly motivated.
  • Communicate research results to supervisor in a timely manner.
  • Familiar with laboratory automation and liquid handling equipment.
  • Mechanistic ADME knowledge and hands-on data generation is a plus.