New England Drug Metabolism Discussion Group
 
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Presentations

 

From the NEDMDG Symposia
The materials on this page are under copyright and should not be used in additional presentations or publications without our express written permission

 

2017

Fall Dinner Meeting - 13 September, 2017 - flyer

"Recent Advances in Drug Transporter and Enzymology Sciences to Enable Drug Design" (Larry Tremaine) - Larry_Tremaine.pdf (2.8MB)

Summer Joint Symposium (NEDMDG & IQ-DMLG) - 31 May, 2017 - flyer

"Quantifying and communicating Uncertainty in Human PK and Dose Prediction" (Douglas Ferguson) - Ferguson.pdf (635KB)

"Use of Target Tissue Concentrations in PK-PD Modeling of Inhaled Drugs" (Ramon Hendrickx) - Hendrickx.pdf (1.03MB)

"How Systems Biology Can Advance Immune Oncology" (Birgit Schoeberl, Ph.D.) Schoeberl.pdf (1.31MB)

"Why Don't Xenografted Tumourmodels translate to Patients?" (Dr. James Yates) Yates.pdf (1.02MB)

Spring Meeting - 8 March, 2017 - flyer

"Drug Disposition in Non-Alcoholic Fatty Liver Didease: Implications for Therapeutics and Drug Development (Rommel G. Tirona, Ph.D.) - Tirona_NEDMDG030817.pdf (4.3MB)


   

2016

Summer Symposium - 13 June, 2016 - flyer

"Qualification of New Translational Safety Biomarkers for Drug Development" (Warren Glaab) - NEDMDG_Meeting_Boston_Glaab_Jun16.pdf (625KB)

"Discovery of Endogenous Biomarkers for Organic Anion Transporter-mediated Drug-Drug Interactions" (Sook Wah Yee) - NEDMDG_YeeSW_v2.pdf (8.4MB)

Spring Meeting - 9 March, 2016 - flyer


   

2015

Winter Meeting - 2 December, 2015 - flyer

"Time Depending Inhibition With Atypical Kinetics, What Is One To DO?" (Ken Korzekwa) - KorzekwaTDI120215.pdf (5.72MB)

Fall Dinner Meeting - 16 September, 2015 - flyer

"Endogenous Probes for Drug-Metabolizing Enzymes and Transporters: Where are we now?" (A. David Rodrigues, Ph.D.) - RODRIGUES_NEDMDG_0915.PDF (3.9MB)

Summer Symposium - 11 June, 2015 - flyer

“DATA, DATA, DATA: Is There Something Else in In Silico ADME?” (Franco Lombardo, Ph.D.) - NEDMDG_flombardo_06112015.pdf (2.4MB)

“Decision-Making with Predictive ADME Data in Context of Experimental Variability” (Brian Mattioni, Ph.D.) - NEDMDG_Mattioni_CompADME_v1.pdf (1.5MB)

“Emerging In Vitro Culture Technologies to Address Challenges in Hepatic Metabolism and Drug Interactions” (Edward L. LeCluyse, Ph.D.) - LeCluyseNEDMDGseminar.pdf (913KB)

Spring Meeting - 11 March, 2015 - flyer

"The Importance of Concept of Fraction of Drug Transported (ft) in Understanding and Predicting Drug Disposition and DDI" (Jashvant (Jash) D. Unadkat, Ph.D.) - UnadkatNEDMG031015.pdf (3.2MB)


   

2014

Winter Meeting - 3 December, 2014 - flyer

Fall Meeting - 10 September, 2014 - flyer

"Are We Getting the Best Return on Investment from Drug-Drug Interaction Studies?" (Lawrence J. Lesko,Ph.D.) - Lesko NEDMG presentation Sept2014.pdf (4.1MB)

Summer Meeting - 19 May, 2014 - flyer

Spring Meeting - 12 March, 2014 - flyer


   

2013

Fall Meeting - 11 September, 2013 - flyer

"Imaging Mass Spectrometry: Molecular Mapping Beyond the Microscope" (Richard M. Caprioli, Ph.D.) - NEDMDG_Caprioli_Presentation_Sept2013.pdf (4.95MB)

Summer Meeting, 4 June, 2013 - flyer

"Plasma Protein Binding: Friend or Foe in Drug Discovery" (Kevin Beaumont, Tristan Maurer) - NEDMDG_PPBpresentation_2.pdf (1MB)

"Do We Need to Optimize Protein Binding in Drug Discovery?" (Xingrong Liu) - ProteinBinding_Liu_6_4_2013.pdf (1.24MB)


   

2012

Winter Meeting, 6 December, 2012 - flyer

“Cytokine-Dependent Regulation of Drug Metabolizing Enzymes as the Basis of Drug Interactions Between Therapeutic Proteins and small Molecules” - This presentation is availbale upon request from Dr. Morgan
("Morgan, Edward T" <etmorga@emory.edu>)

Fall Dinner Meeting, 12 Sep, 2012 - flyer

“PBPK-Based Predictions of Drug-Drug Interactions: Examples and Applications” (Edgar Schuck) - Schuck_PBPK-BasedPredictions.pdf (1.4MB)

Summer Symposium, 13 June 2012 - flyer

"Evolving Trends in Complex Culture Systems and their Utility in Drug Development: Focus on hepatotoxicity" (N. Shangari) - Evolving_Trends_inComplexCultureSystems.pdf (1.6MB)

"Humanized Animal Models for Next Generation Translational Research" (J. Bial) - J.Bial_humanized_animal_models.pdf (1.34MB)

"Evaluation of Chimeric Mice with Humanized Liver to Predict Human Intrinsic Clearance of Drug Molecules at Preclinical Phase" (T. Bohnert) - T.Bohnert_Chimeric_Mice.pdf (602KB)


   

2011

Winter Meeting, 7 Dec, 2011 - flyer

“Mechanism-based Risk Assessment in Drug Development” - BAST_2011_12_07.pdf (1MB)

Fall Dinner Meeting, 21 Sep, 2011 - flyer

“What’s all the Flux About?: An Industry Perspective on the Drug Transporter Whitepaper and Recent Regulatory Guidances” - Polli_Whats_all_the_Flux_About.pdf (1.2MB)

Summer Symposium, 14 June 2011 - flyer

PBPK Modelling and its Applications to Predict Transporter-Mediated
Drug-Drug Interactions - M_Jamei_PBPK_and_Transporters_DDI.pdf (2.1MB)

The In Silico Child: PK/PD Modeling in Pediatric Drug Development- Meibohm.pdf (1MB)

Integrated Quantitative Modeling Approaches to Facilitate Drug Development Decisions - QS-Handout.pdf (696KB)

Spring Meeting, 2 Mar 2011 - flyer

Mechanisms of Idiosyncratic Drug Reactions and Their Implications for Risk Prediction - NEDMDG_mar2011_uetrecht.pdf (3.4MB)


   

2010

 

Winter Meeting, 1 Dec, 2010 - flyer

Fall Dinner Meeting, 22 Sep, 2010 - flyer

Deuteration of Drugs for Pharmacokintic Enhancement: Considerations Essential for Success - NEDMDGSept2010Vaz.pdf (400KB)

Summer Symposium, 9 June, 2010 - flyer

Development of DPP-4 Inhibitors as Antidiabetic Agents - DPP4.pdf (4.8MB)

Improving the Decision-Making Process in the Structural Modification of Drug Candidates (parts 1 & 2) - AK_NEDMDG_2010_Final.pdf (860KB)

Drug-Drug Interactions Between Small Molecules and Bioltherapeutics - NEDMDG_9June2010LKlunk.pdf (4.55MB)

Metabolic Activation and Idiosycratic Drug Toxicity: By Avoiding Structural Alerts, Do We Mitigate Risks? - NEDMDG-2010-Kalgutkar.pdf (4.63MB)

Spring Meeting, 3 Mar 2010 - flyer

Drug Transporters: Report from the International Transporter Consortium; Decisions, Impact and Future Directions - donald-tweedie.pdf (1.5 MB)


   

2009

 

Winter Meeting - 2 December, 2009 - flyer

Summer Symposium, 10 Jun 2009 - flyer

Approaches to Mitigating the Bioactivation Potential of Compounds in Lead Optimization - deepak-dalvie.pdf (2.63MB)

Time Dependent CYP Inhibition in Drug Discovery and Development - scott-grimm.pdf (14.76MB)

Prediction of Drug Metabolism: In Silico and Laboratory
Perspectives from Two Different Angles - lombardo-dennehy.pdf (2.2 MB)

Influence of therapy duration on suppression of emergence of resistance and influences of granulocytes on cell kill - george-drusano.pdf (1.69MB)

Winter Meeting, March 11, 2009 - flyer


   

2008

 

Fall Dinner Meeting, 10 Sep 2008
Metabolites and Safety: Diligence on Safety - Expedience for Patients - scott-obach.pdf (124KB)

Summer Symposium, 4 Jun 2008
Biomarkers and Translational Medicine - donna-mendrick.pdf (3.86 MB)

Novel Translational Biomarkers - peter-obrien.pdf (2.53MB)

Regulatory Application of Quantitative Analysis: Impact of Biomarker Data - yaning-wang.pdf (9MB)

Application of PK/PD Modeling for Developing and Evaluating Rational Strategies for Optimizing Therapy with Mabs - joseph-balthasar.pdf (0.60MB)

Using Biomarkers for Early Phase Dose Selection with Protein Antagonist Drugs - ivan-nestorov.pdf (1.12MB)


Spring Meeting, 12 Mar 2008
The Economics of New Drug Development:
Costs, Risks and Returns -
joseph-dimasi-spring-2008.pdf (1.3MB)



2007


















Download all presentations (10.60 MB, .zip)

Dinner Meeting, 5 Dec 2007
In Vitro to In Vivo Predictions of Drug Interactions:
Going Beyond the I/Ki Ratio -
jash-unadkat.pdf (1.2MB)


Gerald Miwa Retirement Symposium, 9 Apr 2007
DMPK in drug industry: The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters - anthony-lu.pdf (2.1MB)

SUSTIVA: Uncovering the mechanism for the metabolism-dependent, species-selective nephrotoxicity - david-christ.pdf (0.5MB)

DM/PK-guided lead optimization: A historical perspective of a paradigm shift - dhiren-thakker.pdf (0.6MB)

P450 reactions: The basic, the exotic and the important
-
fred-guengerich.pdf (3MB)

Memories from a career - gerald-miwa.pdf (3.6MB)

Heme: the catalytic center and a target in hemoproteins
- paul-ortiz.pdf (1.16MB)


Predicting DMPK of NMEs: What Do We Need in Terms of Science and Tools? - leslie-benet.pdf (0.6MB )

Human Metabolism of a Novel Chemotherapeutic: Illuminating the Mechanisms of P450-Catalyzed Deboronation - scott-daniels.pdf (0.6MB)



2006
Principles of Drug Metabolism - A short course in Fall '06 - flyer

Fall dinner meeting

Current perspectives on Rapid INDs - mitch-cayen.pdf (174KB)







Download all presentations (.zip)

Spring Dinner Meeting , March 2006 - flyer

PK/PD Modeling and Simulation for Compound Progression of Antiretroviral Agents - jeffrey-barrett.pdf (1.4MB)

Statistical spectroscopy and global systems biology approaches in disease modeling - jeremy-nicholson.pdf (3.72MB)

Small Molecule Analysis Using Diverse Separation Techniques Coupled to MicroelectrosprayMass Spectrometry - paul-vouros.pdf (1.37MB)

Ionization Methods in MS - graham-cooks.pdf
(3.84MB)



2005




Download all presentations (.zip)

Winter Meeting , December 2005 flyer
* Now you can register online for the event!

Targeted Bioavailability - Mechanisms of Drug Tissue Distribution - elmquist.pdf (9.8MB)

Hepatic Drug Transport - hoffmaster.pdf (2MB)

PGx of Drug-Transporter Interactions - sadee.pdf (1.6MB)

HT Approaches to AMS - skipper.pdf
(1.25MB)